Thermo Fisher Scientific SMURF2 Polyclonal Antibody
SMURF2 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody로, WB, IHC, ICC/IF에 사용 가능. 인간, 생쥐, 랫트 반응성. 고순도 친화 크로마토그래피 정제, 1 mg/mL 농도, -20°C 보관.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000–1:3,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human SMURF2 (Accession Q9HAU4), corresponding to amino acid residues G221–H271 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2900571 |
Product Specific Information
Antibody detects endogenous levels of total SMURF2.
Target Information
SMURF2 is an E3 ubiquitin-protein ligase that accepts ubiquitin from an E2 conjugating enzyme and transfers it to targeted substrates. It interacts with SMAD1, SMAD2, and SMAD7 to trigger their ubiquitination and proteasome-dependent degradation. SMURF2 enhances SMAD7 inhibitory activity and reduces SMAD2 transcriptional activity. Coexpression with SMAD1 decreases SMAD1 protein levels significantly and SMAD2 levels slightly.
Usage Note
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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