Thermo Fisher Scientific Phospho-ATM (Ser1981) Polyclonal Antibody
Human ATM 단백질의 Ser1981 인산화 부위를 인식하는 sheep 유래 polyclonal antibody. Western blot, ELISA, IP 등 다양한 분석에 적합. Affinity chromatography로 정제된 고순도 제품으로 안정성 우수. -20°C에서 장기 보관 가능.
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Thermo Fisher Scientific Phospho-ATM (Ser1981) Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:10,000–1:25,000 |
| ELISA | 1:2,000–1:10,000 |
| Immunoprecipitation (IP) | 1:500–1:2,000 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Sheep / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to a region near serine 1981 of human ATM conjugated to KLH using maleimide |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | 0.02M potassium phosphate, pH 7.2, with 0.15M NaCl |
| Contains | 0.01% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Store vial at -20°C prior to opening.
- Aliquot contents and freeze at -20°C or below for extended storage.
- Avoid cycles of freezing and thawing.
- Centrifuge if not completely clear after standing at room temperature.
- Stable for several weeks at 4°C as an undiluted liquid.
- Dilute only prior to immediate use.
This affinity-purified antibody is directed against human ATM and recognizes the phosphorylated epitope in native and over-expressed proteins. Reactivity is observed against human ATM; cross-reactivity with other mammalian sources has not been tested.
Target Information
Ataxia-telangiectasia Mutated (ATM) is a protein belonging to the PI3/PI4 kinase family. It plays a key role in repairing double-stranded DNA breaks caused by ionizing radiation and other mutagens. ATM phosphorylates several downstream targets, including P53, Mdm2, BRCA1, and SMC1, acting as a regulator of cell cycle and apoptosis.
Mutations in ATM are associated with ataxia-telangiectasia, a rare autosomal recessive disorder characterized by progressive neurologic degeneration, immunologic deficiency, and increased risk of lymphoid cancer.
ATM becomes autophosphorylated and activated upon exposure to ionizing radiation, triggering a cascade of kinase reactions that regulate DNA damage response.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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