Thermo Fisher Scientific Phospho-ATM (Ser1981) Polyclonal Antibody

Thermo Fisher Scientific Phospho-ATM (Ser1981) Polyclonal Antibody

Applications and Tested Dilution

Product Specifications

Product Specific Information

• Store vial at -20°C prior to opening.
• Aliquot contents and freeze at -20°C or below for extended storage.
• Avoid cycles of freezing and thawing.
• Centrifuge if not completely clear after standing at room temperature.
• Stable for several weeks at 4°C as an undiluted liquid.
• Dilute only prior to immediate use.

This affinity-purified antibody is directed against human ATM and recognizes the phosphorylated epitope in native and over-expressed proteins. Reactivity is observed against human ATM; cross-reactivity with other mammalian sources has not been tested.

Target Information

Ataxia-telangiectasia Mutated (ATM) is a protein belonging to the PI3/PI4 kinase family. It plays a key role in repairing double-stranded DNA breaks caused by ionizing radiation and other mutagens. ATM phosphorylates several downstream targets, including P53, Mdm2, BRCA1, and SMC1, acting as a regulator of cell cycle and apoptosis.
Mutations in ATM are associated with ataxia-telangiectasia, a rare autosomal recessive disorder characterized by progressive neurologic degeneration, immunologic deficiency, and increased risk of lymphoid cancer.
ATM becomes autophosphorylated and activated upon exposure to ionizing radiation, triggering a cascade of kinase reactions that regulate DNA damage response.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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