Thermo Fisher Scientific ITGB5 Polyclonal Antibody
Human, Mouse, Rat에서 반응하는 ITGB5 폴리클로날 항체. Western blot에 1:500–1:1,000 희석으로 사용 가능. 합성 펩타이드(AA 720–770) 면역원으로 제작. 항원 친화 크로마토그래피로 정제된 고순도(>95%) 항체. PBS/glycerol buffer에 보관, 연구용 전용.
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Applications and Tested Dilution
- Western Blot (WB): 1:500–1:1,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to amino acids 720–770 of Human Integrin beta5 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage buffer | PBS, pH 7.2, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping conditions | Wet ice |
| RRID | AB_2802952 |
Product Specific Information
- Purity is >95% by SDS-PAGE.
Target Information
Integrins are important extracellular matrix (ECM) receptor proteins located on cell surfaces. They are heterodimers composed of alpha and beta transmembrane glycoprotein subunits. Around 22 different integrins (different alpha/beta subunit combinations) are found in nature. Integrins are generally present in high concentrations at the cell surface, but, unlike most other cell-surface receptors, they bind ligands with very low affinity. Due to their weak individual binding, integrins need to cluster and bind in groups to effectively bind the ECM. Integrins bind many different ligands including laminin. Each integrin consists of a large N-terminal extracellular domain that binds ECM ligands and a small C-terminal cytoplasmic domain that mediates interaction with the actin cytoskeleton and signaling function.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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