Thermo Fisher Scientific FMRP Monoclonal Antibody (4G9)
인간 FMR1 단백질을 인식하는 마우스 단클론 항체로 WB, IHC, ICC, ELISA 등 다양한 응용에 적합합니다. 비결합형 액상 형태이며 단기 4°C, 장기 -20°C 보관 권장. 연구용으로만 사용 가능.
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Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:500–1:2,000 | View 2 publications |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:200–1:1,000 | — |
| Immunocytochemistry (ICC/IF) | 1:200–1:1,000 | View 1 publication |
| ELISA | 1:10,000 | — |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Published Species | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 4G9 |
| Immunogen | Purified recombinant fragment of human FMR1 expressed in E. coli |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | Not determined |
| Storage Buffer | Ascites |
| Contains | 0.03% sodium azide |
| Storage Conditions | Store at 4°C short term; for long term, store at -20°C avoiding freeze/thaw cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_10979450 |
Product Specific Information
MA5-15499 targets FMR1 in indirect ELISA, IF, IHC, and WB applications and shows reactivity with human samples.
The immunogen is a purified recombinant fragment of human FMR1 expressed in E. coli.
MA5-15499 detects FMR1, which has a predicted molecular weight of approximately 71 kDa.
Target Information
FMR1 binds RNA and is associated with polysomes. The protein may be involved in mRNA trafficking from the nucleus to the cytoplasm.
A trinucleotide repeat in the 5′ UTR is normally found at 6–53 copies, but an expansion to 55–230 repeats causes fragile X syndrome.
Expansion of the trinucleotide repeat may also cause one form of premature ovarian failure.
Multiple alternatively spliced transcript variants encoding different isoforms located in various cellular compartments have been described for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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