Thermo Fisher Scientific CHST1 Polyclonal Antibody

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:1,000

-

ELISA (ELISA)

1 µg/mL

-

Product Specifications

Species Reactivity

Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant fusion protein containing a sequence corresponding to amino acids 62-411 of human CHST1 (NP_0036451) if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:CHST1,uniProtId:O43916-1,ncbiNodeId:9606,antigenRange:62-411,antigenLength:411,antigenImageFileName:PA5-88951_CHST1_O43916-1_Rabbit.svg,antigenImageFileNamePDP:PA5-88951_CHST1_O43916-1_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

2.39 mg/mL

Purification

Affinity Chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.01% thimerosal

Storage conditions

-20° C, Avoid Freeze/Thaw Cycles

Shipping conditions

Wet ice

RRID

AB_2805247

Product Specific Information

Immunogen sequence: HILILATTRS GSSFVGQLFN QHLDVFYLFE PLYHVQNTLI PRFTQGKSPA DRRVMLGASR DLLRSLYDCD LYFLENYIKP PPVNHTTDRI FRRGASRVLC SRPVCDPPGP ADLVLEEGDC VRKCGLLNLT VAAEACRERS HVAIKTVRVP EVNDLRALVE DPRLNLKVIQ LVRDPRGILA SRSETFRDTY RLWRLWYGTG RKPYNLDVTQ LTTVCEDFSN SVSTGLMRPP WLKGKYMLVR YEDLARNPMK KTEEIYGFLG IPLDSHVARW IQNNTRGDPT LGKHKYGTVR NSAATAEKWR FRLSYDIVAF AQNACQQVLA QLGYKIAASE EELKNPSVSL VEERDFRPFS; Positive Samples: Mouse liver, Mouse kidney, Rat brain; Cellular Location: Golgi apparatus membrane, Single-pass type II membrane protein

Target Information

Carbohydrate sulfotransferase 1 (CHST1), also referred to as KSGal6ST or KSST, is a keratan sulfate sulfotransferase. It is predominantly expressed in brain and skeletal muscle and localizes to the trans-Golgi network. CHST1 is responsible for mediating the sulfation of keratan in the cornea, which is important in maintaining corneal transparency. In particular, CHST1 catalyzes the transfer of sulfate groups from 3-phosphoadenosine 5-phosphosulfate to position six of internal or terminal galactose residues (preferentially the residues adjacent to sulfated GlcNAc) on growing keratan sulfate chains. CHST1 also contributes to the generation of L-selectin ligands. Mutations in the CHST1 gene may play a role in macular corneal dystrophy (MCD).

⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.