Thermo Fisher Scientific TRAF5 Monoclonal Antibody (OTI2G3), TrueMAB
인간 TRAF5 단백질(aa 334-557)을 항원으로 제작된 Mouse IgG1 단클론 항체. Western blot에 1:2,000 희석으로 사용 가능. NF-kB 및 JNK 신호전달 연구에 적합하며, 액상 형태로 -20°C 보관.
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Applications
- Western Blot (WB): Tested dilution 1:2,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI2G3 |
| Immunogen | Human recombinant protein fragment corresponding to amino acids 334–557 of human TRAF5 produced in E. coli |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage buffer | PBS with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
Target Information
Tumor necrosis factor (TNF)-induced signaling occurs via association of TNF receptor (TNFR) with adaptor proteins such as TRAFs. TRAFs are cytoplasmic adapter proteins mediating signal transduction from TNF-receptor superfamily members (e.g., RANK, CD30, CD40) and the interleukin-1 receptor. The carboxy-terminal region of TRAFs is required for self-association and receptor interaction following ligand-induced oligomerization. Six TRAF members (TRAF1–TRAF6) have been identified. TRAF5 is a 558-amino-acid protein involved in NF-kB and c-Jun N-terminal kinase/stress-activated protein kinase activation by TNF receptor superfamily members, including CD27, CD30, CD40, and lymphotoxin-beta receptor. TRAF5 gene disruption causes defects in CD40-CD27 mediated lymphocyte activation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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