Thermo Fisher Scientific ABCD4 Polyclonal Antibody
ABCD4 단백질을 인식하는 Thermo Fisher Scientific의 고트 폴리클로날 항체로, Human에 반응하며 WB 및 IHC(P) 실험에 적합합니다. 고순도 정제, 안정적 액상 형태로 제공되며 연구용으로만 사용됩니다.
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- PA518969
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Thermo Fisher Scientific ABCD4 Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 0.3–1 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | 3.75 µg/mL |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Goat / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide sequence (RDDIDNPDQRISQD) corresponding to internal amino acids of ABCD4 (aa 136–150) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Ammonium sulfate precipitation |
| Storage Buffer | TBS, pH 7.3, with 0.5% BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | −20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_10980630 |
Product Specific Information
- Predicted to react with canine, mouse, and rat based on sequence homology.
- Tested in Peptide ELISA: antibody detection limit dilution 8,000.
Target Information
The peroxisomal membrane contains several ATP-binding cassette (ABC) transporters, ABCD1–4, which are present in the human peroxisome membrane. All four proteins act as ABC half-transporters that dimerize to form active transporters.
A mutation in the ABCD1 gene causes X-linked adreno-leukodystrophy (X-ALD), a peroxisomal disorder affecting lipid storage.
ABCD2 in mouse is highly expressed in the brain and adrenal organs, which are adversely affected in X-ALD.
The peroxisomal membrane comprises major proteins PMP22 and ABCD3; ABCD3 is associated with irregularly shaped vesicles that may be defective peroxisomes or precursors.
ABCD1 localizes to peroxisomes, while ABCB7 is involved in heme transport from mitochondria to cytosol.
Usage Note
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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