Thermo Fisher Scientific TTBK2 Polyclonal Antibody

Applications

Tested Dilution

Publications

Western Blot (WB)

0.04-0.4 µg/mL

-

Immunohistochemistry (Paraffin) (IHC (P))

1:500-1:1,000

-

Product Specifications

Species Reactivity

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant protein corresponding to Human TTBK2. Recombinant protein control fragment (Product #RP-91429). if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:TTBK2,uniProtId:Q6IQ55-1,ncbiNodeId:9606,antigenRange:819-921,antigenLength:1244,antigenImageFileName:PA5-53728_TTBK2_Q6IQ55-1_Rabbit.svg,antigenImageFileNamePDP:PA5-53728_TTBK2_Q6IQ55-1_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.25 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.2, with 40% glycerol

Contains

0.02% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Wet ice

RRID

AB_2649034

Product Specific Information

Immunogen sequence: TTEPLDVTKT QTFSVVPNQD KNNEIMKLLT VGTSEISSRD IDPHVEGQIG QVAEMQKNKI SKDDDIMSED LPGHQGDLST FLHQEGKREK ITPRNGELFH CVS

Highest antigen sequence identity to the following orthologs: Mouse - 74%, Rat - 78%.

Target Information

Tau tubulin kinase (TTBK2) is a serine/threonine kinase whose substrates are thought to include the tau and tubulin proteins. Mutations in the TTBK2 gene cause spinocerebellar ataxia type 11 (SCA11), a neurodegenerative disease characterized by progressive ataxia and atrophy of the cerebellum and brainstem. Recent studies have shown that increased levels of TTBK2 expression in kidney carcinoma and melanoma cell lines increases resistance to the chemotherapeutic agent Sunitinib, and that reduction of TTBK2 though the use of siRNA sensitized these cell lines to the effects of Sunitib, suggesting that TTBK2 can be used as a resistance marker as well a potential target to overcome resistance.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.