Thermo Fisher Scientific SCN4A Polyclonal Antibody

Applications

• Immunocytochemistry (ICC/IF): 0.25–2 µg/mL

Product Specifications

Product Specific Information

Immunogen sequence:
MKQASYMYRH SHDGSGDDAP EKEGLLANTM SKMYGHENGN SSSPSPEEKG E

Target Information

Voltage-gated sodium channels are selective ion channels that regulate the permeability of sodium ions in excitable cells. During the propagation of an action potential, sodium channels allow an influx of sodium ions, which rapidly depolarize the cell.
These channels consist of:

• A pore-forming alpha subunit
• A noncovalently associated beta1 subunit
• A disulfide-linked beta2 subunit

The beta subunits regulate channel expression, modulate gating, and function as cell adhesion molecules.
Alpha subunits type I and III are mainly found in neuronal cell bodies and proximal processes, while type II is abundant along axons.
Beta1 subunit is expressed in brain, skeletal, and cardiac muscle. In the brain, beta1 and beta2 are highly expressed in Purkinje cells, and beta1 is also found in pyramidal cells of the deep cerebellar nuclei.
Impaired voltage-gated sodium channels can lead to diseases such as myotonia.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.