Thermo Fisher Scientific Nkx2.6 Polyclonal Antibody
Nkx2.6 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody로, WB, IHC, ELISA 등 다양한 응용에 적합합니다. 항원 친화 크로마토그래피로 정제되었으며, 인간 및 생쥐 시료에 반응합니다. 연구용으로만 사용 가능합니다.
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Applications
| Application | Tested Dilution | Notes |
|---|---|---|
| Western Blot (WB) | 1.0 µg/mL | |
| Immunohistochemistry (Paraffin) (IHC (P)) | 5 µg/mL | |
| ELISA | Assay-Dependent |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | 15 amino acid synthetic peptide near the center of human NKX2-6 (amino acids 170–220) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term; for long term, store at -20°C and avoid freeze/thaw cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2718617 |
Target Information
Members of the NK-2 family of homeodomain proteins are key regulators of growth and development in several tissues, including brain, heart, and pancreas.
Nkx-2.5, also designated cardiac specific homeobox protein (Csx), is a homolog of the Drosophila tinman protein and is essential for normal cardiovascular development. Expression of Nkx-2.5 during cardiomyogenesis is required for cardiac septation, in which a single atrium and ventricle are separated into four chambers.
Nkx-2.5 binds to DNA as a monomer, a homodimer, or as a heterodimer with Nkx-2.3 or Nkx-2.6, suggesting that specific protein-protein interactions are involved in its transcriptional regulatory function.
Nkx-2.6, also a homolog of the Drosophila tinman protein, is expressed in the caudal pharyngeal pouches, caudal heart progenitors, sinus venosus, outflow tract of the heart, and a short segment of the gut between stages E8.5 and E10.5 of embryogenesis. Expression of Nkx-2.6 overlaps with that of Nkx-2.5 in the pharynx and heart. However, Nkx-2.6 mutant mice are viable and fertile, suggesting that Nkx-2.6 plays a compensatory function to Nkx-2.5.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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