Thermo Fisher Scientific TNFSF18 Monoclonal Antibody (3C11)
인간 TNFSF18 단백질을 인식하는 Mouse IgG1 단클론 항체로 ELISA에 사용 가능. GITRL 관련 면역 연구에 적합하며, 액상 형태로 제공. PBS(pH 7.4) 버퍼에 보존제 없이 저장되며 -20°C 보관 권장.
- 카탈로그번호
- H00008995-M25
- 판매단위
- pk
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Applications
- ELISA (ELISA)
Tested Dilution: 10 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 3C11 |
| Immunogen | TNFSF18 (AAH69111.1, 50 a.a. ~177 a.a) partial recombinant protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | See Label |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
Sequence of this protein is as follows:
QLETAKEPCM AKFGPLPSKW QMASSEPPCV NKVSDWKLEI LQNGLYLIYG QVAPNANYND VAPFEVRLYK NKDMIQTLTN KSKIQNVGGT YELHVGDTID LIFNSEHQVL KNNTYWGIIL LANPQFIS
Target Information
The tumor necrosis factor (TNF) and TNF receptor (TNFR) gene superfamilies regulate numerous biological functions including cell proliferation, differentiation, and survival through activation of NF-kappa-B and various mitogen-activated protein kinases.
The glucocorticoid-induced tumor necrosis factor receptor (GITR) is an emerging member expressed on CD4+ CD25+ regulatory T cells and plays crucial roles in immune regulation.
Its ligand, GITRL, is expressed in endothelial and antigen-presenting cells, activating NF-kappa-B and modulating apoptotic and T cell responses.
Studies suggest that the GITRL-GITR pathway involves both NIK and TRAF2.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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