Thermo Fisher Scientific TNFSF18 Monoclonal Antibody (2E2)

Applications

• ELISA (ELISA): Tested dilution 10 µg/mL

Product Specifications

Target Information

The tumor necrosis factor (TNF) and TNF receptor (TNFR) gene superfamilies regulate numerous biological functions including cell proliferation, differentiation, and survival through activation of NF-κB and mitogen-activated protein kinases.
The glucocorticoid-induced tumor necrosis factor receptor (GITR) is an emerging member of this family, expressed on CD4⁺ CD25⁺ regulatory T cells, and plays a crucial role in immune regulation.
Its ligand, GITRL, is expressed in endothelial and antigen-presenting cells and can activate NF-κB, induce both pro- and anti-apoptotic effects, inhibit the suppressive activity of regulatory T cells, and co-stimulate responder T cells through GITR.
Dominant negative forms of NIK and TRAF2 expressed in transfected 293 cells substantially inhibited NF-κB activation, suggesting that the GITRL–GITR pathway involves both NIK and TRAF2.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.