Thermo Fisher Scientific Human DACT3 Synthetic Peptide

Applications

Control (Ctrl)

• Assay-dependent

Blocking Assay (BLOCK)

• Assay-dependent

Product Specifications

Product Specific Information

This peptide corresponds to 17 amino acids near the amino terminus of human Dact3.
PEP-0750 can be used as a blocking peptide with polyclonal antibody PA5-20630.

Target Information

The Wnt signaling cascade is a conserved process in multicellular animals that plays important roles during development and can contribute to cancer and other diseases. Many members of this pathway are also expressed in postnatal tissues such as the brain.
Dact3, a member of the Dact protein family, binds to Disheveled (Dvl), a cytoplasmic protein essential to Wnt signaling. It is expressed in the ventral region of maturing somites, limb bud and branchial arch mesenchyme, embryonic CNS, and the adult brain.
Recent evidence shows that Dact3 acts as a negative regulator of Wnt/beta-catenin signaling and is repressed at the transcriptional level in colorectal cancer, associated with bivalent histone modifications. This repression can be reversed by pharmacological agents targeting histone methylation and deacetylation, suggesting Dact3 as a potential therapeutic target.
At least three isoforms of Dact3 are known to exist.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.