Thermo Fisher Scientific LKB1 Polyclonal Antibody
LKB1 단백질을 인식하는 Thermo Fisher Scientific의 폴리클로날 항체로, WB, IHC, ICC/IF에 사용 가능. 인간, 생쥐, 영장류 반응성. 정제된 액상 형태로 -20°C 보관. 연구용으로만 사용.
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Thermo Fisher Scientific LKB1 Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Non-human primate |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human STK11 (Accession Q15831), corresponding to amino acid residues R405–Q433 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2818486 |
Product Specific Information
Antibody detects endogenous levels of total LKB1.
Target Information
LKB1 (also known as STK11 - Serine/threonine-protein kinase STK11) is a tumor suppressor belonging to the serine/threonine kinase family.
It physically associates with p53 and regulates specific p53-dependent apoptosis pathways.
LKB1 is present in both the cytoplasm and nucleus and translocates to mitochondria during apoptosis.
It functions as a master upstream protein kinase, regulating AMPK-related kinases as well as AMPK.
Mutations in the LKB1 gene are associated with Peutz-Jeghers syndrome.
Usage Note
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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