Thermo Fisher Scientific SPIB Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 1–2 µg/mL

Immunohistochemistry (Paraffin) (IHC (P))

• Tested Dilution: 2.5 µg/mL

Product Specifications

Product Specific Information

Positive controls that may be used include: Human Prostate Tissue Lysate

Target Information

Spi-B is a transcription factor belonging to a subfamily of ETS transcription factors with a conserved ETS domain that mediates specific DNA binding. Spi-B may form homotypic interactions and is known to interact with IRF4, CREBBP, EP300, SPI1/PU.1 related, JUN and TBP.
As a sequence-specific transcriptional activator, it binds to the PU-box, a purine-rich DNA sequence (5’-GAGGAA-3’) that can act as a lymphoid-specific enhancer.
Two isoforms of Spi-B are reported. Spi-B is usually expressed in plasmacytoid dendritic cells (pDCs), also known as type 2 DC precursors (pre-DC2) or natural interferon (IFN)-producing cells, and promotes their development and blocks viral replication.
Spi-B is not expressed in T-cells or granulocytes but may be present in stem cell populations of the liver and B-cells where it helps in B-cell receptor (BCR) signaling, normal B-cell development, and antigenic stimulation.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

제품 이미지

(이미지 없음)