Thermo Fisher Scientific SOCS3 Monoclonal Antibody (532CT13.5.3)

Applications

• Western Blot (WB): 1:500–1:1,600

Product Specifications

Target Information

Cytokine receptor signaling is negatively regulated by a family of Src homology 2 domain-containing adaptor molecules termed SOCS (Suppressor of Cytokine Signaling). To date, eight members of the SOCS family have been recognized: SOCS-1, 2, 3, 4, 5, 6, 7, and CIS. Structurally, SOCS proteins comprise an N-terminal variable region, a central SH2 domain, and a C-terminal SOCS box motif. These proteins form part of a classical negative feedback loop that regulates cytokine signal transduction via a STAT-induced transcriptional mechanism. Transcription of SOCS genes occurs rapidly in response to cytokines, and once produced, SOCS family members inhibit signaling through distinct mechanisms.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.