Thermo Fisher Scientific IWS1 Polyclonal Antibody
IWS1 단백질을 인식하는 Thermo Fisher Scientific의 rabbit polyclonal 항체. Human 및 Rat 시료에 반응하며 IHC(P) 등 다양한 응용에 적합. 고순도 affinity chromatography 정제, 안정적인 PBS/glycerol buffer 제공. 연구용으로만 사용 가능.
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- PA567630
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- pk
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Thermo Fisher Scientific IWS1 Polyclonal Antibody
Applications
- Immunohistochemistry (Paraffin) (IHC (P))
Tested Dilution: 1:20–1:100
Publications: - [References not provided]
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthesized peptide derived from human IWS1 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.7 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 40% glycerol |
| Contains | 0.05% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2688512 |
Product Specific Information
Predicted to react with Rat samples.
Target Information
Transcription factor which plays a key role in defining the composition of the RNA polymerase II (RNAPII) elongation complex and in modulating the production of mature mRNA transcripts. Acts as an assembly factor to recruit various factors to the RNAPII elongation complex and is recruited to the complex via binding to the transcription elongation factor SUPT6H bound to the C-terminal domain (CTD) of the RNAPII subunit RPB1 (POLR2A).
The SUPT6H:IWS1:CTD complex recruits mRNA export factors (ALYREF/THOC4, EXOSC10) as well as histone modifying enzymes (such as SETD2) to ensure proper mRNA splicing, efficient mRNA export, and elongation-coupled H3K36 methylation—a signature chromatin mark of active transcription.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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