Thermo Fisher Scientific NISCH Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 1:500–1:2,000

Product Specifications

Product Specific Information

Antibody detects endogenous levels of total NISCH.

Target Information

Acts either as the functional imidazoline-1 receptor (I1R) candidate or as a membrane-associated mediator of the I1R signaling.
Binds numerous imidazoline ligands that induce initiation of cell-signaling cascades triggering cell survival, growth, and migration.
Activation by the agonist rilmenidine increases phosphorylation of MAPK1 and MAPK3 in rostral ventrolateral medulla (RVLM) neurons, leading to rilmenidine-evoked hypotension.
Blocking activation with efaroxan abolishes rilmenidine-induced MAPK phosphorylation in RVLM neurons.
Functions as a modulator of Rac-regulated signal transduction pathways, suppressing Rac1-stimulated cell migration by interacting with PAK1 and inhibiting its kinase activity.
Also inhibits Pak-independent Rac signaling by interacting with RAC1 and inhibiting Rac1-stimulated NF-κB and cyclin D1 promoter activation.
Reduces LIMK1 Tyr-508 phosphorylation, inhibiting LIMK1 kinase activity.
Inhibits Rac-induced cell migration and invasion in breast and colon epithelial cells and lamellipodia formation when overexpressed.
Plays a role in protection against apoptosis and enhances insulin activation of MAPK1 and MAPK3 through association with IRS4.
Overexpression induces redistribution of cell surface ITGA5 integrin to intracellular endosomal structures.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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