Thermo Fisher Scientific SDPR Polyclonal Antibody

Applications

Tested Dilution

Publications

Immunocytochemistry (ICC/IF)

0.25-2 µg/mL

-

Product Specifications

Species Reactivity

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant protein corresponding to Human CAVIN2. Recombinant protein control fragment (Product #RP-107133). if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:SDPR,uniProtId:O95810-1,ncbiNodeId:9606,antigenRange:12-98,antigenLength:425,antigenImageFileName:PA5-84530_SDPR_O95810-1_Rabbit.svg,antigenImageFileNamePDP:PA5-84530_SDPR_O95810-1_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

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Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.4 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.2, with 40% glycerol

Contains

0.02% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Wet ice

RRID

AB_2791681

Product Specific Information

Immunogen sequence: QHPGSDMRQE KPSSPSPMPS STPSPSLNLG NTEEAIRDNS QVNAVTVLTL LDKLVNMLDA VQENQHKMEQ RQISLEGSVK GIQNDLT

Target Information

The serum deprivation-response protein (SDPR) is a calcium-independent phospholipid-binding protein whose expression is increased in serum-starved cells. SDPR is a substrate for protein kinase C (PKC) phosphorylation and recruits the polymerase I and transcript release factor (PTRF) to caveolae. Removal of this protein causes caveolae loss and its over-expression results in caveolae deformation and membrane tubulation. Both SDPR and PTRF, as well as the other member of the cavin family PRKCDBP were down regulated in breast cancer cell lines and breast tumor tissue, suggesting that expression of the cavin family proteins could be a useful prognostic indicator of breast cancer progression.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.