Thermo Fisher Scientific AGR2 Monoclonal Antibody (OTI5D8), TrueMAB
AGR2 단백질을 검출하기 위한 Thermo Fisher Scientific의 단클론 항체. Western blot 및 IHC(Paraffin) 검증 완료. 인간, 생쥐, 랫드 반응성. 동결건조 형태로 제공되며, 재구성 후 1 mg/mL 농도. 암 연구 및 단백질 발현 분석에 적합.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:2,000 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Mouse / IgG2b |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI5D8 |
| Immunogen | Human recombinant protein fragment corresponding to amino acids 21–175 of human AGR2 produced in E. coli |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.3, with 8% trehalose |
| Contains | No preservative |
| Storage Conditions | –20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
For reconstitution, add 100 µL of distilled water to achieve a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments, perform an additional desalting step using Zeba Spin Desalting Columns (7K MWCO, 0.5 mL, Product #89882).
Target Information
AGR2 (anterior gradient protein 2) and AGR3 are members of the anterior gradient homolog family. These secreted cytoplasmic proteins are involved in metastasis induction and p53 tumor suppressor inhibition.
They may serve as molecular markers and potential therapeutic targets for hormone-responsive breast tumors.
AGR2 expression is upregulated in prostate, breast, lung, renal, and endometrial carcinomas. It shows positive correlation with estrogen receptor (ER) expression and negative correlation with epidermal growth factor receptor (EGFR).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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