Thermo Fisher Scientific c-Met Polyclonal Antibody
Thermo Fisher Scientific의 c-Met Polyclonal Antibody는 인간 c-Met 단백질을 인식하는 고품질 항체로, Western blot, IHC, ICC 등 다양한 응용에 적합합니다. 항원 친화 크로마토그래피로 정제되었으며, 연구용으로 암 관련 신호전달 연구에 활용됩니다.
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Applications
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | Assay-dependent | View 6 publications |
| Immunohistochemistry (IHC) | - | View 4 publications |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:10–1:100 | View 1 publication |
| Immunocytochemistry (ICC/IF) | - | View 1 publication |
| ELISA | Assay-dependent | View publications |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Published Species | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide derived from the C-terminal of the human c-Met protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.25 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.4 |
| Contains | 0.1% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2533999 |
Target Information
MET (c-MET) is a receptor-like tyrosine kinase whose dysregulation has been linked to many types of human malignancies. After activation by its ligand, MET interacts with PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, and STAT3, leading to activation of signaling cascades including RAS-ERK, PI3K-AKT, and PLCγ-PKC pathways.
MET plays a key role in embryonic development processes such as gastrulation, muscle and neuron development, angiogenesis, and kidney formation. In adults, it contributes to wound healing, organ regeneration, and tissue remodeling. Dysregulation of MET has been associated with cancers including gastric, renal, and breast, making it a valuable target for cancer therapeutics and diagnostics.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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