Thermo Fisher Scientific SCF Polyclonal Antibody
SCF 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody입니다. Western blot, IHC, ICC/IF에 적합하며 다양한 종에서 반응합니다. 항원 친화 크로마토그래피로 정제되었으며 PBS/BSA 버퍼에 보관됩니다. 연구용으로만 사용 가능합니다.
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Thermo Fisher Scientific SCF Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | 5 µg/mL |
| Immunocytochemistry (ICC/IF) | 1–5 µg/mL |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Non-human primate |
| Host/Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide conjugated to KLH derived from within residues 50–150 of Human SCF |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 1% BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C or -80°C if preferred |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_10990344 |
Product Specific Information
- For Western Blot, this antibody has non-specific bands at 120 kDa and 50 kDa.
- Heat mediated antigen retrieval recommended prior to tissue staining.
- Predicted to react with rat, sheep, goat, horse, cow, cat, dog, pig, and rhesus monkey based on sequence homology.
Target Information
Stem cell factor (SCF) is the ligand of the c-Kit oncogene and is expressed by various structural and inflammatory cells in the airways. Binding of SCF by the c-Kit receptor leads to receptor homodimerization and activation of signaling pathways such as PI-3, PLC-gamma, Jak/STAT, and MAP kinase. SCF expression induces mast cell survival and release of histamine, pro-inflammatory cytokines, and chemokines. Inhibition of the SCF/c-Kit pathway reduces histamine levels, mast cell and eosinophil infiltration, IL-4 production, and airway hyperresponsiveness, making it a potential therapeutic target for inflammatory diseases such as asthma. At least two isoforms of SCF are known to exist.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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