Thermo Fisher Scientific SCF Polyclonal Antibody

Thermo Fisher Scientific SCF Polyclonal Antibody

Applications and Tested Dilution

Product Specifications

Product Specific Information

• For Western Blot, this antibody has non-specific bands at 120 kDa and 50 kDa.
• Heat mediated antigen retrieval recommended prior to tissue staining.
• Predicted to react with rat, sheep, goat, horse, cow, cat, dog, pig, and rhesus monkey based on sequence homology.

Target Information

Stem cell factor (SCF) is the ligand of the c-Kit oncogene and is expressed by various structural and inflammatory cells in the airways. Binding of SCF by the c-Kit receptor leads to receptor homodimerization and activation of signaling pathways such as PI-3, PLC-gamma, Jak/STAT, and MAP kinase. SCF expression induces mast cell survival and release of histamine, pro-inflammatory cytokines, and chemokines. Inhibition of the SCF/c-Kit pathway reduces histamine levels, mast cell and eosinophil infiltration, IL-4 production, and airway hyperresponsiveness, making it a potential therapeutic target for inflammatory diseases such as asthma. At least two isoforms of SCF are known to exist.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.