Thermo Fisher Scientific MCFD2 Polyclonal Antibody
Human MCFD2 단백질을 인식하는 Rabbit Polyclonal Antibody로, IHC(P)에서 1:20–1:50 희석 비율로 사용 가능. 항원 친화 크로마토그래피로 정제된 액상 형태이며, PBS buffer와 glycerol 포함. ER-Golgi 단백질 수송 연구에 적합.
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Applications
- Immunohistochemistry (Paraffin) (IHC (P)): 1:20–1:50 dilution
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human MCFD2. Recombinant protein control fragment (Product #RP-102623) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.05 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2643810 |
Product Specific Information
Immunogen sequence:
ASFSQPGSMG LDKNTVHDQE HIMEHLEGVI NKPEAEMSPQ ELQLHYFKMH DYDGNNLLDG LELSTAITHV HKEEGSEQAP LMSEDELIN
Highest antigen sequence identity to orthologs:
- Mouse: 83%
- Rat: 85%
Target Information
Multiple coagulation factor deficiency protein 2 (MCFD2) is localized in the endoplasmic reticulum-Golgi intermediate compartment (ERGIC) through a direct, calcium-dependent interaction with LMAN1.
The MCFD2-LMAN1 complex forms a specific cargo receptor for the transport of selected proteins from the endoplasmic reticulum to the Golgi apparatus.
Mutations in the MCFD2 gene may cause factor V and factor VIII combined deficiency (F5F8D), an autosomal recessive human bleeding disorder characterized by the reduction of both clotting proteins.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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