Thermo Fisher Scientific HCG-beta Recombinant Rabbit Monoclonal Antibody (HCGb, 1985R)

Applications

• Immunohistochemistry (Paraffin) (IHC (P))

Tested Dilution: 1–2 µg/mL

Product Specifications

Product Specific Information

• For Immunohistochemistry (PFA fixed): incubate antibody for 30 min at room temperature.
• Staining of formalin-fixed tissues requires heating tissue sections in 10 mM Tris with 1 mM EDTA, pH 9.0, for 45 min at 95°C, followed by cooling at room temperature for 20 minutes.

Target Information

hCG beta is the beta chain of human chorionic gonadotropin (hCG), a 40 kDa glycoprotein hormone produced by trophoblastic cells of the placenta beginning 10–12 days after conception.
hCG consists of alpha and beta subunits that are non-covalently associated. The alpha subunit is similar to those found in pituitary hormones (FSH, LH, TSH), while the beta subunit confers biological specificity.
During early pregnancy, hCG stimulates the corpus luteum to produce progesterone, maintaining the secretory endometrium.
Trace amounts of hCG are present in non-pregnant urine and serum but rise sharply during pregnancy.
Diseases associated with hCG dysfunction include gestational trophoblastic tumor and hydatidiform mole.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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