Thermo Fisher Scientific HRAS Monoclonal Antibody (OTI1D9), TrueMAB

Applications and Tested Dilution

Product Specifications

Product Specific Information

For reconstitution, add 100 µL distilled water to achieve a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments, perform an additional desalting step using Zeba Spin Desalting Columns (7K MWCO, 0.5 mL, Product #89882).

Target Information

Monomeric G protein Ras acts as a molecular switch linking receptor and nonreceptor tyrosine kinase activation to various downstream signaling pathways leading to distinct cytoplasmic or nuclear events.
Each mammalian cell contains three Ras proto-oncogenes coding for closely related Ras proteins: H-, K-, and N-Ras.
Oncogenic mutations in Ras genes occur in approximately 30% of human cancers. Constitutive activation of Ras due to mutations or overexpression promotes proliferation and inhibits apoptosis.

• K-Ras mutations: common in pancreatic, colorectal, and non-small-cell lung carcinomas
• H-Ras mutations: common in bladder, kidney, and thyroid carcinomas
• N-Ras mutations: found in melanoma, hematologic malignancies, and hepatocellular carcinoma

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.