Thermo Fisher Scientific proNGF Polyclonal Antibody

Applications and Tested Dilution

Product Specifications

Product Specific Information

• Reconstitute antibody with 50 µL of double distilled water (DDW).
• The reconstituted solution can be stored at 4°C for up to 1 week.
• For longer storage, aliquot and keep at -20°C.
• Avoid multiple freeze–thaw cycles.
• Centrifuge before use (10,000 × g, 5 min).

Peptide sequence: (C)SPRVLFSTQPPPTSSDTLDLD
Homology: Mouse – identical; Human – 16/21 amino acids identical.

Target Information

Nerve Growth Factor (NGF) influences the survival and differentiation of various neuronal and non-neuronal cells by binding to specific cell surface receptors.

• High affinity receptors mediate signal transduction (Mr 158,000 complex with NGF).
• Low affinity receptors form an Mr 100,000 complex.
• Human and rat NGF receptor genes show over 90% homology.
• NGF plays a role in growth and differentiation of sympathetic and sensory neurons.
• Mutations in NGF gene are linked to hereditary sensory and autonomic neuropathy type 5 (HSAN5).
• Dysregulation of NGF expression is associated with allergic rhinitis.

For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.