Thermo Fisher Scientific Leptin Recombinant Rabbit Monoclonal Antibody (002)
인간 Leptin 단백질을 인식하는 토끼 단클론 항체로, ICC/IF 및 유세포분석에 사용 가능. HEK293 세포에서 발현된 재조합 형식이며, Protein A로 정제됨. PBS 용액 내 보존제로 없는 액상 형태로 제공.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Immunocytochemistry (ICC/IF) | 1:20–1:100 |
| Flow Cytometry (Flow) | 1:25–1:100 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | 002 |
| Immunogen | Recombinant Human Leptin/LEP Protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS |
| Contains | No preservative |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2866597 |
Target Information
Leptin is a 167 amino acid protein hormone that plays a critical role in regulating body weight, metabolism, and reproductive function. It has a molecular weight of approximately 16 kDa and is encoded by the obese (ob) gene. Leptin is primarily secreted by adipocytes, correlating with total body fat mass, and is also produced in smaller quantities by gastric epithelial cells and the placenta.
Leptin receptors are highly expressed in hypothalamic regions that regulate feeding, energy expenditure, and body temperature, as well as in T lymphocytes and vascular endothelial cells. Through these receptors, leptin influences food intake, thermogenesis, fatty acid oxidation, hematopoiesis, angiogenesis, wound healing, immune responses, and reproductive development. Defects in leptin production can lead to severe hereditary obesity in both rodents and humans.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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