Thermo Fisher Scientific PHKB Polyclonal Antibody
PHKB 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody로, Human, Mouse, Rat에 반응합니다. Western blot에 적합하며, 125 kDa의 내인성 단백질 검출이 가능합니다. 고순도(>95%) 항체로 연구용으로 사용됩니다.
- 판매단위
- pk
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Applications
- Western Blot (WB)
Tested Dilution: 1:500–1:1,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to amino acids 699–744 of human PHKB |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term, store at -20°C avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2553867 |
Product Specific Information
- Detects endogenous PHKB protein (~125 kDa).
- Purity >95% by SDS-PAGE.
Target Information
Phosphorylase kinase is a hexadecameric enzyme composed of four copies of four subunits encoded by PHKA, PHKB, PHKG, and PHKD genes. This serine/threonine-specific kinase converts glycogen phosphorylase b to glycogen phosphorylase a, releasing glucose-1-phosphate from glycogen.
PHKB (Phosphorylase b kinase regulatory subunit beta) is a 1093 amino acid regulatory component of phosphorylase kinase. Mutations in PHKB cause glycogen storage disease type 9B, characterized by mild hepatomegaly, slightly elevated transaminases and plasma lipids, and improvement with age.
Four isoforms of PHKB are produced by alternative splicing.
For Research Use Only. Not for use in diagnostic procedures or resale without authorization.
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