Thermo Fisher Scientific TAB182 Polyclonal Antibody
Human TAB182 단백질을 인식하는 Rabbit Polyclonal Antibody로, IHC(P)에서 1:200~1:500 희석 비율로 사용 가능. 항원 친화 크로마토그래피로 정제되었으며, PBS 기반 버퍼에 40% glycerol 포함. 단기 4°C, 장기 -20°C 보관 권장.
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- PA558172
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Applications
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1:200–1:500
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human TAB182. Recombinant protein control fragment (Product #RP-97361). |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.2 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2648176 |
Product Specific Information
- Immunogen sequence:
EVLASPDRLW GSRLTFNHDG SSRYGPRTYG TTTAPRDEDG STLFRGWSQE GPVKSPAECR EEHSKTPEER SLPSDLAFNG DLAKAASSEL PAD - Highest antigen sequence identity:
- Mouse: 71%
- Rat: 66%
Target Information
TAB182 (tankyrase 1-binding protein of 182 kDa) was identified in a two-hybrid screen for tankyrase 1-interacting proteins.
Tankyrase 1 is a poly (ADP-ribose) polymerase (PARP) that ribosylates TRF1, a negative regulator of telomere length. Ribosylation of TRF1 inhibits its binding and induces telomere elongation.
TAB182 and TRF1 bind multiple overlapping sites on the tankyrase 1 ankyrin domain, suggesting TAB182 may act as a scaffold for higher-order protein complex formation at telomeres.
TAB182 also localizes to the cytoplasmic cortical actin network, indicating potential cytoplasmic roles.
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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