Thermo Fisher Scientific Phospho-c-Myc (Thr58) Recombinant Rabbit Monoclonal Antibody (ARC1534)
Phospho-c-Myc (Thr58) 단백질을 특이적으로 인식하는 재조합 토끼 단클론 항체입니다. Western blot 및 ELISA에 적합하며, 세포 증식 및 종양 관련 신호전달 연구에 활용됩니다. 고순도 친화 크로마토그래피 정제 및 안정한 액상 보관 형태로 제공됩니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| ELISA | 1 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | ARC1534 |
| Immunogen | A synthetic phosphorylated peptide around T58 of human c-Myc (P01106) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.65 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS, pH 7.3, with 50% glycerol, 0.05% BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2849747 |
Product Specific Information
- Immunogen sequence: LPTPP
Target Information
The c-Myc protein is a 62 kDa transcription factor encoded by the c-Myc gene on human chromosome 8q24.
It is frequently activated in various tumor cells and plays key roles in:
- Cellular proliferation, differentiation, apoptosis, and cell cycle progression
- Phosphorylation at Thr58/Ser62 by kinases such as GSK3, CDK, ERK2, and JNK
- Vasculogenesis and angiogenesis during tumor development
Abnormal expression or amplification of c-Myc is associated with multiple cancers, including lung, breast, colon, and neuroblastoma.
Translocation of the c-Myc locus is also implicated in Burkitt’s lymphoma and other B-cell proliferative disorders.
Antibodies recognizing c-Myc epitopes are useful for detecting overexpressed or tagged proteins in various research applications.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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