Thermo Fisher Scientific p23 Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 1:500–1:2,000

Immunoprecipitation (IP)

• Tested Dilution: 1–5 µL/mg of lysate

Product Specifications

Target Information

Steroid receptors are ligand-dependent intracellular proteins that regulate gene transcription by binding to specific DNA sequences upon hormone activation. Prior to activation, these receptors associate with various proteins, including heat shock proteins (HSP70, HSP90), immunophilins (FKBP52, FKBP54, CyP-40), and other proteins such as p23, p60, and p48.
p23, together with HSP70, HSP90, and p60, forms a transient complex with the progesterone receptor (PR). The cloned human p23 encodes a 160-amino-acid protein highly conserved across species, with no homology to previously identified proteins. It is an acidic phosphoprotein with an aspartic acid-rich C-terminal domain and multiple phosphorylation sites.
In vitro studies suggest p23 binds to HSP90 and is essential for HSP90 and CyP-40 binding to PR. Although its exact function remains unclear, p23 plays a significant role in PR function.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.