Thermo Fisher Scientific PLSCR1 Recombinant Rabbit Monoclonal Antibody (ARC2028)
PLSCR1 단백질을 인식하는 토끼 단클론 항체로, Western blot, IHC, ICC 및 ELISA에 적합합니다. 인간, 마우스, 랫트 반응성을 가지며 HEK293 세포에서 발현된 재조합 항체입니다. 친화 크로마토그래피로 정제되었으며, PBS/glycerol buffer에 보관됩니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| Immunohistochemistry (Paraffin) (IHC-P) | 1:50–1:200 |
| Immunocytochemistry (ICC/IF) | 1:50–1:200 |
| ELISA | 1 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | ARC2028 |
| Immunogen | Synthetic peptide corresponding to amino acids 1–100 of human Phospholipid Scramblase 1 (PLSCR1) (NP_066928.1) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.61 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.3, with 50% glycerol, 0.05% BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | –20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2897984 |
Product Specific Information
- Positive Samples: HT-29, Mouse lung
- Immunogen sequence:
MDKQNSQMNA SHPETNLPVG YPPQYPPTAF QGPPGYSGYP GPQVSYPPPP AGHSGPGPAG FPVPNQPVYN QPVYNQPVGA AGVPWMPAPQ PPLNCPPGLE
Target Information
Phospholipid Scramblase 1 (PLSCR1) is a calcium-dependent plasma membrane protein involved in the transbilayer movement of phosphatidylserine and other phospholipids upon calcium influx. This process contributes to membrane remodeling and phosphatidylserine exposure in apoptotic or injured cells, leading to cell death. PLSCR1 expression is induced by interferons and cytokines, suggesting a role in cytokine signaling. EGF stimulation causes tyrosine phosphorylation at residues 69 and 74, enabling interaction with Shc and linking Src kinase activation to EGF receptor signaling.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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