KrosFlo® FS-500 System

KrosFlo® FS-500 System for 1.25 L - 500 L Volumes

KrosFlo® FS-500 enables true walk-away automation and modernization of flat sheet processes from 1.25 L up to 500 L, supporting membrane surface area from 0.5 -1.5 m2. KrosFlo® FS-500 centers around a Quattroflow™ QF1200 SU diaphragm pump which delivers flow rates up to 18 LPM and allows for high pressure applications up to 4 bar. The KrosFlo® FS-500 design also utilizes a base plate for optimum flow path length and component geometry, as well as a permeate side flow meter.

1.25 L - 500 L volume
0.5 - 1.5 m2 filtration area

KrosFlo® FS EXCLUSIVE SET OF SINGLE-USE AND AUTOMATED FEATURES
KrosFlo® FS Systems integrate up to 11 components with specifications to process volumes between 140 mL and 500 L. Each system integrates up to three pumps, one main diaphragm pump and two auxiliary peristaltic pumps. Sensors and analytics include up to two scales, flow meter and the Konduit which measures conductivity.

1. KF Comm 2 Software
2. 4-piston diaphragm pump
3. KR1 auxiliary pump
4. Automatic Back Pressure Control Valve (ABV)
5. Scale
6. Konduit monitor
7. TangenX® Flat Sheet Cassettes
8. ProConnex® Flow Path
9. Permeate flow sensor
10. Stir plate
11. KrosFlo® FS-500 base plate

• AUTOMATED MULTI-STEP PROCESSES
  Walk-away multi-step automation with automated TMP based on 13 built-in process modes
• PLUG-AND-PLAY MODULES
  Repligen-exclusive advanced microprocessor-based controller enables integrated plug-and-play modularity of all system components
• COMPLETE MODERN FUNCTIONALITY
  Complete and up-to-date 21CFR Part 11 compliance and centralized control and monitoring through a single interface

KrosFlo® FS PROPRIETARY DIFFERENTIATING FUNCTIONS

• Automatic Back Pressure Control Valve
  A Repligen-exclusive technology, the Automatic Back Pressure Control Valve adds transmembrane pressure (TMP) control to every TFF process, reducing operator hands-on-time and improving process reproducibility.

Automatically adjust tubing pinch distance according to user-defined set-points
Maintain uniform TMP throughout process run, decreasing membrane fouling
Control permeate pressure and flow during microfiltration applications
Use with compatible tubing sizes 13, 14, 16, 25, HP15, 17, HP24, 18, HP35, 36, and HP36
Activate automatically using inlet, retentate, permeate or transmembrane pressures

• Transfer bi-directional data through proprietary board
  An advanced microprocessor-based controller is integrated into the main KrosFlo® FS System pumps, enabling plug-and-play hardware component behavior. Bi-directional communication is established between the KF Comm 2 software and hardware components, such as the Automatic Back Pressure Control Valve, scales, auxiliary pumps and the Konduit device.

• Menu-driven software for optimized TFF
  KF Comm 2 Software provides a modern, graphically driven interface for process monitoring and control. Create new experiments based on 13 programmed modes, customize batch reports and plug-and-play hardware components. Add an optional 21 CFR Part 11 feature package for regulated environments.

Start a run in only 4 clicks
Select from 13 pre-programmed modes
Operate securely on Microsoft SQL® database for stability

LEVERAGE INTEGRATED DIAPHRAGM PUMP FOR FLAT SHEET PROCESSES

The KrosFlo® FS Systems achieve an unparalleled combination of configurability and automation and compliance for flat sheet TFF processes. All components, either directly or indirectly, connect to the main KrosFlo® FS diaphragm pump, which then communicates with the KF Comm 2 software for control and monitoring.

• Configure a minimal number of components for simple applications such as concentration (C) or diafiltration (D)
• Plug-and-play additional components for fractionation (F) and multi-step processes (i.e. CDC/D/C)

C

D, CD, CDC, CFC

CFC/D/C, CDDC, CDCD

SCALE EFFORTLESSLY FROM LAB TO PILOT MANUFACTURING

Transition seamlessly from small scale to larger scale processes. The KrosFlo® FS-15 handles volumes as small as 140 mL to 15 L. The KrosFlo® FS-500 is capable of larger volumes from 1.25 L to 500 L. These two KrosFlo® FS TFF Systems share common hardware architecture, software and pump technology.

Scale-up and scale-down with a single platform​
Configure across applications (C, D and CFC/D/C)​
Operate 21 CFR Part 11 compliant software built on secure Microsoft® SQL Server ​