Thermo Fisher Scientific POT1 Polyclonal Antibody
Human POT1 단백질을 인식하는 Rabbit Polyclonal 항체로, Western blot에 적합합니다. 항원 친화 크로마토그래피로 정제되었으며, 0.73 mg/mL 농도의 액상 형태입니다. 4°C 단기 보관, -20°C 장기 보관이 권장됩니다.
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Applications
- Western Blot (WB): 1:500–1:3,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant fragment corresponding to a region within amino acids 87–379 of Human POT1 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.73 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | 0.1M Tris glycine, pH 7, with 20% glycerol |
| Contains | 0.01% thimerosal |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2549017 |
Product Specific Information
- Recommended positive controls: 293T, A431, Jurkat
- Predicted reactivity: Pig (85%)
- Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
POT1 is a component of the telomerase ribonucleoprotein (RNP) complex essential for chromosome end replication. It is part of the double-stranded telomeric DNA-binding TRF1 complex involved in telomere length regulation by cis-inhibition of telomerase. POT1 also binds single-stranded telomeric DNA, acting as a downstream effector of the TRF1 complex to transduce telomere maintenance and length information. It binds specifically to telomeric single-stranded sequences (5′-TTAGGG-3′ repeats) and requires TERT for activity, though it does not enhance TERT activity.
⚠ WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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