Thermo Fisher Scientific TYMS Monoclonal Antibody (OTI1C5), TrueMAB

Applications

• Western Blot (WB)
  Tested Dilution: 1:2,000

Product Specifications

Product Specific Information

For reconstitution, add 100 µL distilled water to achieve a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments using this carrier-free antibody, perform an additional desalting step (e.g., Zeba Spin Desalting Columns, 7K MWCO, 0.5 mL, Product #89882).

Target Information

Thymidylate Synthase (TS) catalyzes the conversion of deoxyuridine monophosphate (dUMP) to deoxythymidine monophosphate (dTMP), a key step in DNA biosynthesis.
TS is a critical target for fluoropyrimidines, a class of antineoplastic drugs widely used for treating solid tumors.
Both 5-FU and fluorodeoxyuridine are converted in tumor cells to FdUMP, which inactivates TS through formation of a ternary covalent complex in the presence of the folate cofactor 5,10-methylenetetrahydrofolate.
Expression of TS is associated with response to 5-fluorouracil (5-FU) in colorectal, gastric, head and neck, and breast carcinomas.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

제품 이미지

(이미지 정보 없음)