Thermo Fisher Scientific Obiltoxaximab Chimeric Recombinant Human Monoclonal Antibody

Applications

• ELISA (Assay-dependent)

Product Specifications

Product Specific Information

• Endotoxin level: < 0.01 EU/µg by LAL method
• Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
• Store at 2–8°C for up to one week.
• Store at -20 to -80°C for up to twelve months from the date of receipt.

Target Information

Obiltoxaximab is a biosimilar that targets Anthrax protective antigen. Anthrax infection is initiated by inhalation, ingestion, or cutaneous contact with Bacillus anthracis endospores. B. anthracis produces three polypeptides that comprise the anthrax toxin: protective antigen (PA), lethal factor (LF), and edema factor (EF).
PA binds to two related proteins on the cell surface — tumor epithelial marker 8 (TEM8)/anthrax toxin receptor (ATR) and capillary morphogenesis protein 2 (CMG2). Following PA binding, PA is cleaved into two fragments by a furin-like protease. The bound fragment interacts with LF and EF, forming a complex that is endocytosed, allowing the translocation of LF and EF into the cytoplasm. These toxins can induce rapid cell death and organism mortality.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.