Thermo Fisher Scientific Inebilizumab Humanized Recombinant Human Monoclonal Antibody
CD19 타깃 인간화 재조합 단일클론 항체로, ELISA 등 연구용에 적합. CHO 세포에서 발현되며 Protein A로 정제. 액상 형태, 1.32 mg/mL 농도, PBS(pH 7.4) 버퍼에 보존. -20°C 이하에서 장기 보관 가능.
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Applications
- ELISA (Assay-dependent)
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host/Isotype | Human / IgG1, kappa |
| Expression System | CHO cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Immunogen | Human CD19 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1.32 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2911208 |
Product Specific Information
- Endotoxin level < 0.01 EU/µg by LAL method
- Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
- Store at 2–8°C for one week; at -20 to -80°C for twelve months from the date of receipt.
Target Information
Inebilizumab is a biosimilar antibody that targets CD19. CD19 belongs to the immunoglobulin superfamily and has two Ig-like domains. It is expressed on 100% of peripheral B cells and also found on certain myeloid leukemia cells. CD19 serves as a key functional regulator of normal and malignant B cell proliferation and is expressed in all B cell precursor leukemias. This molecule lowers the threshold for antigen receptor-dependent stimulation and acts as a signal-amplifying coreceptor for the B cell receptor (BCR). Mutations in CD19 lead to hypogammaglobulinemia, while overexpression results in B cell hyperactivity.
For Research Use Only. Not for use in diagnostic procedures or resale without express authorization.
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