Thermo Fisher Scientific CRHBP Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 1:500–1:2,000

ELISA

• Tested Dilution: 1 µg/mL

Product Specifications

Product Specific Information

• Immunogen sequence:
  TLGHVNGLQL KKSSAGCEGI GDFVELLGGT GLDPSKMTPL ADLCYPFHGP AQMKVGCDNT VVRMVSSGKH VNRVTFEYRQ LEPYELENPN GNSIGEFCLS GL
• Positive Samples: U-87MG, LO2, 293T

Target Information

Response to stress in mammals requires an intact hypothalamic-pituitary-adrenal axis. The proximal part of the response is mediated by secretion of corticotropin-releasing hormone (CRH) by the paraventricular nucleus of the hypothalamus. CRH is a 41 amino acid peptide derived by enzymatic cleavage from a 191 amino acid preprohormone. It is produced not only in the hypothalamus but also in peripheral tissues such as T lymphocytes and is highly expressed in human placenta. Glucocorticoids stimulate placental CRH synthesis and secretion in primary cultures of human placenta, contrasting with suppression in hypothalamus.
Human plasma contains a CRH-binding protein (CRH-BP, also designated CRF-BP) which inactivates CRH and may prevent inappropriate pituitary-adrenal stimulation in pregnancy. The gene encoding CRF-BP maps to human chromosome 5q11.2–q13.3.

⚠ WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.