Thermo Fisher Scientific COL1A2 Polyclonal Antibody
COL1A2 단백질을 검출하는 Rabbit Polyclonal Antibody로, WB, IHC, ICC 등 다양한 응용에 사용 가능. 인간 시료 반응성. 항원 친화 크로마토그래피로 정제되었으며, 고농도(1 mg/mL) 액상 형태로 제공. 연구용으로만 사용.
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Thermo Fisher Scientific COL1A2 Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:500–1:3,000 | View 1 publication |
| Immunohistochemistry (IHC) | - | View 1 publication |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:100 | - |
| Immunohistochemistry (Frozen) (IHC (F)) | 1:100 | - |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 | - |
Product Specifications
| Item | Description |
|---|---|
| Species Reactivity | Human |
| Published Species | Not Applicable |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthesized peptide derived from internal region of human Collagen I alpha2 (aa 1–21) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS (pH 7.4), with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2635365 |
Product Specific Information
This antibody detects endogenous levels of total COL1A2 protein.
Target Information
The COL1A2 gene encodes the pro-alpha2 chain of type I collagen, which forms a triple helix structure with two alpha1 chains and one alpha2 chain. Type I collagen is a fibril-forming collagen found in most connective tissues, including bone, cornea, dermis, and tendon.
Mutations in this gene are associated with:
- Osteogenesis imperfecta (types I–IV)
- Ehlers-Danlos syndrome (type VIIB, recessive classical type)
- Idiopathic osteoporosis
- Atypical Marfan syndrome
Symptoms from COL1A2 mutations are generally less severe than those from COL1A1 mutations, reflecting the distinct roles of alpha2 chains in matrix integrity. Three transcripts have been identified for this gene due to alternate polyadenylation signals.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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