Thermo Fisher Scientific TIMD4 Polyclonal Antibody
Human TIMD4를 인식하는 Rabbit Polyclonal Antibody로 Western blot 및 IHC(P) 검증됨. 항원 친화 크로마토그래피로 정제된 액상 제품이며, PBS 버퍼에 40% 글리세롤과 0.02% sodium azide 포함. 단기 4°C, 장기 -20°C 보관 권장.
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Applications
Western Blot (WB)
- Tested Dilution: 0.04–0.4 µg/mL
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1:500–1:1,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human TIMD4. Recombinant protein control fragment (Product # RP-90600) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.4 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping conditions | Wet ice |
| RRID | AB_2648470 |
Product Specific Information
Immunogen sequence:
VFTTANTCLS LTPSTLPEEA TGLLTPEPSK EGPILTAESE TVLPSDSWSS VESTSADTVL LTSKESKVWD LPSTSHVSMW KTSDSVSSPQ PGASDTAVPE QNKTTKTGQM DGIPMSMKNE MP
Sequence identity:
Highest antigen sequence identity to the following orthologs:
- Mouse: 28%
- Rat: 28%
Target Information
The T cell immunoglobulin and mucin domain containing protein (TIM) family encodes cell surface receptors involved in the regulation of T helper (Th)-1 and -2 cell-mediated immunity.
TIM-4, preferentially expressed on macrophages and dendritic cells, is the natural ligand of TIM-1, leading to T-cell expansion and cytokine production.
Unlike other members of the TIM family, TIM-4 lacks a putative tyrosine phosphorylation signal sequence in its intracellular domain.
The TIM-4 gene maps to a locus associated with predisposition to asthma in both mice and humans and may be considered a candidate gene for asthma susceptibility.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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