Thermo Fisher Scientific BAP3 Polyclonal Antibody

Applications

Tested Dilution

Publications

Immunohistochemistry (Paraffin) (IHC (P))

1:200-1:500

-

Product Specifications

Species Reactivity

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant protein corresponding to Human BAP3. Recombinant protein control fragment (Product #RP-90656). if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:BAP3,uniProtId:O94812-1,ncbiNodeId:9606,antigenRange:776-915,antigenLength:1187,antigenImageFileName:PA5-53347_BAP3_O94812-1_Rabbit.svg,antigenImageFileNamePDP:PA5-53347_BAP3_O94812-1_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.2 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.2, with 40% glycerol

Contains

0.02% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Wet ice

RRID

AB_2638472

Product Specific Information

Immunogen sequence: ATLFYTELLR KKVDTQPGAA GEAVSEALCV VLNNVELVRK AAGQALKGLA WPEGATGPEG VLPRPLLSCT QALDDDLQRE AHTVTAHLTS KMVGDIRKYV QHISLSPDSI QNDEAVAPLM KYLDEKLALL NASLVKGNLS

Highest antigen sequence identity to the following orthologs: Mouse - 87%, Rat - 89%.

Target Information

BAP3 was initially identified through interaction in a yeast two-hybrid system with the brain-specific angiogenesis inhibitor 1, a p53-target gene that encodes a seven-span transmembrane protein member of the secretin receptor family. BAP3 is predominantly expressed in the brain and possess high homology with Munc13 and synaptotagmin, suggesting that BAP3 may play a role in regulating neurotransmitter release. Recent experiments have shown that BAP3 is induced in certain tumors such as desmoplastic small round cell tumor. Ectopic expression of BAP3 in tumor cells dramatically enhances growth in low serum conditions and colony formation in soft agar, suggesting that the regulated exocytotic pathway may play a role in cancer cell proliferation.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.