Thermo Fisher Scientific BAP3 Polyclonal Antibody
인간 BAP3 단백질에 특이적인 Rabbit Polyclonal Antibody. IHC(P)에서 1:200~1:500 희석으로 사용 가능. 항원 친화 크로마토그래피 정제 및 PBS/glycerol 버퍼로 안정화. 신경전달 및 종양 관련 연구용으로 적합.
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Applications
- Immunohistochemistry (Paraffin) (IHC (P)): 1:200–1:500 dilution
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human BAP3. Recombinant protein control fragment (Product # RP-90656) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.2 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping conditions | Wet ice |
| RRID | AB_2638472 |
Product Specific Information
Immunogen sequence:
ATLFYTELLR KKVDTQPGAA GEAVSEALCV VLNNVELVRK AAGQALKGLA WPEGATGPEG VLPRPLLSCT QALDDDLQRE AHTVTAHLTS KMVGDIRKYV QHISLSPDSI QNDEAVAPLM KYLDEKLALL NASLVKGNLS
Highest antigen sequence identity to the following orthologs:
- Mouse: 87%
- Rat: 89%
Target Information
BAP3 was initially identified through interaction in a yeast two-hybrid system with the brain-specific angiogenesis inhibitor 1, a p53-target gene that encodes a seven-span transmembrane protein member of the secretin receptor family.
BAP3 is predominantly expressed in the brain and shows high homology with Munc13 and synaptotagmin, suggesting that BAP3 may play a role in regulating neurotransmitter release.
Recent studies indicate that BAP3 is induced in certain tumors such as desmoplastic small round cell tumor. Ectopic expression of BAP3 in tumor cells enhances growth in low serum conditions and colony formation in soft agar, suggesting that the regulated exocytotic pathway may contribute to cancer cell proliferation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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