Thermo Fisher Scientific Phospho-IR/IGF1R (Tyr1158) Polyclonal Antibody, Alexa Fluor 488
Alexa Fluor 488으로 표지된 Phospho-IR/IGF1R (Tyr1158) 폴리클로날 항체로, 인간 IR/IGF1R 인산화 부위를 인식합니다. ICC/IF에 사용 가능하며, 마우스와 랫트에서도 반응이 예측됩니다. 고순도 항체로 세포 성장 및 대사 연구에 적합합니다.
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Applications
- Immunocytochemistry (ICC/IF)
Tested Dilution: 1:500
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic phosphopeptide derived from the region of IR/IGF1R that contains tyrosine 1158 of the human insulin receptor (IR) (tyrosine 1131 for IGF1R) |
| Conjugate | Alexa Fluor™ 488 |
| Excitation / Emission Max | 499 / 520 nm |
| Form | Liquid |
| Purification | Size-exclusion chromatography |
| Storage Buffer | Dulbecco’s PBS, pH 7.3, with 0.2% BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2802658 |
Product Specific Information
This antibody is predicted to react with mouse and rat.
Target Information
Insulin and Insulin-like Growth Factor receptors are transmembrane tyrosine kinase receptors that play critical roles in development, cell growth, and metabolism. Binding of insulin or IGF-1 to the extracellular domain of IR and IGF1R leads to receptor autophosphorylation and activation of intrinsic tyrosine kinase activity, enabling phosphorylation of substrates.
Phosphorylation sites unique to each receptor contribute to signaling differences. The catalytic loops within the tyrosine kinase domains contain a three-tyrosine motif: Tyr1158, 1162, and 1163 (IR) and Tyr1131, 1135, and 1136 (IGF1R). Autophosphorylation proceeds sequentially, initiating at Tyr1162 (or Tyr1135), followed by Tyr1158 (IGF-1R Tyr1131) and Tyr1163 (IGF-1R Tyr1136), leading to full activation of IR and IGF1R.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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