Thermo Fisher Scientific PSD93 Recombinant Rabbit Monoclonal Antibody (JM41-04)
PSD93 단백질을 인식하는 토끼 모노클로날 항체로, Western blot, Flow cytometry, Immunoprecipitation에 적합. HEK293 세포에서 발현된 재조합 항체이며, 인간, 생쥐, 랫트 반응성. 단백질 A로 정제되어 높은 특이성과 재현성을 제공.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Flow Cytometry (Flow) | 1:50–1:100 |
| Immunoprecipitation (IP) | Assay-dependent |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | JM41-04 |
| Immunogen | Synthetic peptide within human PSD93 aa 600–660 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | TBS, pH 7.4, with 40% glycerol, 0.05% BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2911617 |
Product Specific Information
- Positive Control: Hela cell lysate, SH-SY5Y cell lysate, SH-SY5Y
- Subcellular Location: Cell membrane, postsynaptic density, synapse, membrane, axon, perikaryon
Target Information
PSD-93 (also known as chapsyn-110) is a plasma membrane-associated protein found in synaptic junctions. It is uniquely expressed in Purkinje neuron cell bodies and dendrites. PSD-93 contains three PDZ domains (~90 amino acids each), one SH3 domain, and a carboxyl-terminal guanylate kinase homology (GuK) domain that is enzymatically inactive.
PDZ-domain interactions are thought to play a role in receptor and channel clustering, contributing to neuronal plasticity. PSD-93 is believed to cluster NMDA receptors and shaker-type potassium channels at the synaptic membrane.
NMDA receptors and shaker-type potassium channels share a C-terminal T/SXV motif that interacts with PSD-93 PDZ domains. Additionally, neuronal nitric oxide synthase (nNOS), which lacks this motif but has its own PDZ domain, can associate with PSD-93 through PDZ–PDZ interactions.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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