Thermo Fisher Scientific PXN Polyclonal Antibody, MaxPab

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:1,000

-

in situ PLA (PLA)

1:1200

-

Product Specifications

Species Reactivity

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

PXN (XP_001132665.1, 1 a.a. approximately 262 a.a) full-length human protein. if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:Paxillin,uniProtId:P49023-1,ncbiNodeId:9606,antigenRange:1-591,antigenLength:591,antigenImageFileName:H00005829-D01P_Paxillin_P49023-1_Rabbit.svg,antigenImageFileNamePDP:H00005829-D01P_Paxillin_P49023-1_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

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Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

See Label

Purification

Affinity chromatography

Storage buffer

PBS, pH 7.4

Contains

no preservative

Storage conditions

-20° C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

Product Specific Information

Sequence of this protein is as follows: MPDTFNSRSP SVEGSLWAVG TESQGRDWRH LPTITSELSG APRCHTVPCA GSTALQEPGE PQGPPASPSC PEEALAATWE QPWASEVFGP ERMPPSGAAR SFQEVTEPAV VAVDRQAIFP DTWTLTEEHG LQQERPRPEP GRLGSSSPAS VTTEQLGAKM TERGSVARPT QGPETPRSPE GTTEAATQDG KEQPELPCAM AMGTPSTTER ISTSGQAGTS SHGCWAWPLA GLSVGRSSLT ACSLPLCACL LGQKMLRHCG RT

Target Information

Paxillin is a focal adhesion protein and a substrate for several tyrosine kinases such as src, FAK, and p210BRC/ABL. The tyrosine phosphorylation of paxillin is affected by conditions that change cell-cell adhesion. Paxillin associates tightly with FAK and Crk through its SH2 domain. This interaction is independent of the extracellular matrix. Although paxillin was initially discovered in fibroblasts, its phosphorylation may also be important during neurite extension during differentiation.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.