Thermo Fisher Scientific PXN Polyclonal Antibody, MaxPab
Thermo Fisher Scientific의 PXN Polyclonal Antibody는 인간 Paxillin 단백질을 인식하는 토끼 유래 다클론 항체입니다. Western blot 및 in situ PLA에 적합하며, PBS 기반 무보존제 액상 형태로 공급됩니다. 연구용으로만 사용 가능합니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| in situ PLA (PLA) | 1:1200 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | PXN (XP_001132665.1, 1 a.a. – approximately 262 a.a), full-length human protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | See Label |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
Protein sequence:
MPDTFNSRSP SVEGSLWAVG TESQGRDWRH LPTITSELSG APRCHTVPCA GSTALQEPGE PQGPPASPSC PEEALAATWE QPWASEVFGP ERMPPSGAAR SFQEVTEPAV VAVDRQAIFP DTWTLTEEHG LQQERPRPEP GRLGSSSPAS VTTEQLGAKM TERGSVARPT QGPETPRSPE GTTEAATQDG KEQPELPCAM AMGTPSTTER ISTSGQAGTS SHGCWAWPLA GLSVGRSSLT ACSLPLCACL LGQKMLRHCG RT
Target Information
Paxillin is a focal adhesion protein and a substrate for several tyrosine kinases such as src, FAK, and p210BRC/ABL. The tyrosine phosphorylation of paxillin is affected by conditions that change cell-cell adhesion. Paxillin associates tightly with FAK and Crk through its SH2 domain, and this interaction is independent of the extracellular matrix. Although paxillin was initially discovered in fibroblasts, its phosphorylation may also be important during neurite extension and differentiation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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