Thermo Fisher Scientific PXN Polyclonal Antibody, MaxPab
Human Paxillin 단백질을 인식하는 Thermo Fisher Scientific의 PXN 폴리클로날 항체로, Western blot에 최적화되어 있습니다. 고순도 친화성 크로마토그래피로 정제되었으며, PBS(pH 7.4) 용액 형태로 제공됩니다. 연구용으로만 사용 가능합니다.
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Applications
Western Blot (WB)
- Tested Dilution: 1:500–1:1,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | PXN (XP_001132665.1, 1 a.a. ~ 262 a.a) full-length human protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | See Label |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
Sequence of this protein is as follows:
MPDTFNSRSP SVEGSLWAVG TESQGRDWRH LPTITSELSG APRCHTVPCA GSTALQEPGE PQGPPASPSC PEEALAATWE QPWASEVFGP ERMPPSGAAR SFQEVTEPAV VAVDRQAIFP DTWTLTEEHG LQQERPRPEP GRLGSSSPAS VTTEQLGAKM TERGSVARPT QGPETPRSPE GTTEAATQDG KEQPELPCAM AMGTPSTTER ISTSGQAGTS SHGCWAWPLA GLSVGRSSLT ACSLPLCACL LGQKMLRHCG RT
Target Information
Paxillin is a focal adhesion protein and a substrate for several tyrosine kinases such as src, FAK, and p210BRC/ABL. The tyrosine phosphorylation of paxillin is affected by conditions that change cell-cell adhesion. Paxillin associates tightly with FAK and Crk through its SH2 domain. This interaction is independent of the extracellular matrix. Although paxillin was initially discovered in fibroblasts, its phosphorylation may also be important during neurite extension during differentiation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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