Thermo Fisher Scientific TNFRSF10B Monoclonal Antibody (OTI4B12), TrueMAB
TNFRSF10B 단백질을 인식하는 Mouse Monoclonal Antibody로, Western Blot 및 IHC(P)에서 검증됨. Human 시료에 반응하며, Lyophilized 형태로 제공. 재구성 후 약 1 mg/mL 농도로 사용 가능. 연구용으로만 사용.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:150 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI4B12 |
| Immunogen | Human recombinant protein fragment corresponding to amino acids 203–411 of human TNFRSF10B produced in E. coli |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.3, with 8% trehalose |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
For reconstitution, add 100 µL of distilled water to achieve a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments, perform an additional desalting step (e.g., using Zeba Spin Desalting Columns, 7K MWCO, 0.5 mL, Product #89882).
Target Information
DR5 (Apo2, TRAIL-R2, TRICK2, KILLER) is a death domain-containing receptor for TRAIL that mediates TRAIL-induced apoptosis.
It belongs to the TNF-receptor superfamily and transduces apoptosis signals via TNFSF10/TRAIL/APO-2L.
DR5 activation requires FADD, a death domain adaptor protein, and overexpression can induce apoptosis and activate NF-κB.
DR5 is expressed in various cell types, notably in lymphocytes and spleen.
Dysfunction of DR5 has been associated with squamous cell carcinoma and diffuse infiltrative lymphocytosis syndrome.
For Research Use Only.
Not for use in diagnostic procedures or resale without express authorization.
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