Thermo Fisher Scientific TNFRSF10B Monoclonal Antibody (OTI5G5), TrueMAB

Applications and Tested Dilution

• Immunohistochemistry (Paraffin) (IHC (P)): 1:150

Product Specifications

Product Specific Information

For reconstitution, add 100 µL distilled water to obtain a final antibody concentration of approximately 1 mg/mL.
When using this carrier-free antibody for conjugation experiments, perform an additional desalting step (recommended: Zeba Spin Desalting Columns, 7K MWCO, 0.5 mL, Product #89882).

Target Information

DR5 (Apo2, TRAIL-R2, TRICK2, KILLER) is a death domain-containing receptor for TRAIL that mediates TRAIL-induced apoptosis.
DR5 belongs to the TNF receptor superfamily and contains an intracellular death domain. It can be activated by TNFSF10/TRAIL/APO-2L to transduce apoptotic signals.
Studies using FADD-deficient mice indicate that FADD, a death domain adaptor protein, is essential for DR5-mediated apoptosis.
Two transcript variants encoding different DR5 isoforms and one non-coding transcript have been identified. Overexpression of DR5 induces apoptosis and activates NF-κB.
DR5 is expressed in various cell types, particularly in lymphocytes and spleen.
Dysfunction of DR5 is associated with diseases such as squamous cell carcinoma and diffuse infiltrative lymphocytosis syndrome.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.