Thermo Fisher Scientific Collagen Type I Polyclonal Antibody, FITC

Applications and Tested Dilutions

Product Specifications

Product Specific Information

• Store vial at 4°C prior to restoration.
• Restore with 0.05 mL of deionized water (or equivalent).
• For extended storage, aliquot and freeze at -20°C or below.
• Avoid repeated freeze/thaw cycles.
• Centrifuge if solution is not clear after standing at room temperature.
• Stable for several weeks at 4°C as an undiluted liquid.
• Dilute only prior to immediate use.
• Expiration date: 1 year from date of restoration.

Typically negligible cross-reactivity against other types of collagens was detected by ELISA.
This antibody reacts with most mammalian Type I collagens and shows negligible cross-reactivity with Type II, III, IV, V, and VI collagens.
Non-specific cross-reaction with other human serum or extracellular matrix proteins is negligible.

Target Information

Collagen I is a fibril-forming Type I collagen composed of two alpha-1 chains and one alpha-2 chain. It is abundant in connective tissues such as bone, cornea, dermis, and tendon.
Mutations in the COL1A2 gene are associated with osteogenesis imperfecta, Ehlers-Danlos syndrome, idiopathic osteoporosis, and atypical Marfan syndrome.
Chromosomal translocations involving Collagen Type I genes and PDGFB gene are linked to dermatofibrosarcoma protuberans due to unregulated growth factor expression.
Two transcripts have been identified from alternate polyadenylation signals.

For Research Use Only. Not for use in diagnostic procedures.

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