Thermo Fisher Scientific Leptin Polyclonal Antibody
Western blot, IHC, ELISA 등 다양한 응용에 적합한 Leptin 폴리클로날 항체. Rabbit IgG 기반으로 Bovine, Human, Mouse, Rat 반응성. Protein A로 정제된 고순도 액상 항체로, -20°C 보관. 체중 조절 및 대사 연구에 활용 가능.
- 카탈로그번호
- BS-0409R
- 판매단위
- pk
카탈로그
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:300 |
| Immunohistochemistry (Paraffin) (IHC-P) | 1:400 |
| Immunohistochemistry (Frozen) (IHC-F) | 1:100–1:500 |
| Immunocytochemistry (ICC/IF) | 1:50–1:200 |
| ELISA | 1:500–1:1,000 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Bovine, Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KLH-conjugated synthetic peptide derived from bovine Leptin |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | 0.01M TBS, pH 7.4, with 1% BSA, 50% glycerol |
| Contains | 0.02% ProClin 300 |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
Leptin is a 167-amino acid protein hormone that regulates body weight, metabolism, and reproductive function. It has a molecular mass of approximately 16 kDa and is encoded by the ob (obese) gene. Leptin is primarily secreted by adipocytes, reflecting total body fat mass, and is also produced in smaller amounts by stomach epithelial cells and the placenta.
Leptin receptors are highly expressed in the hypothalamus, T lymphocytes, and vascular endothelial cells. Through these receptors, leptin influences feeding behavior, energy expenditure, thermogenesis, and body temperature regulation. It also plays roles in hematopoiesis, angiogenesis, wound healing, inflammation, immune responses, pubertal development, and fetal growth.
Leptin has been studied in the context of obesity, anorexia nervosa, insulin resistance, and hypertension. Mutations affecting leptin production can cause severe hereditary obesity in both rodents and humans.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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