Thermo Fisher Scientific MRPS12 Polyclonal Antibody
Human MRPS12 단백질을 인식하는 Rabbit Polyclonal 항체로, Western blot에 적합합니다. N-terminal 합성 펩타이드를 면역원으로 사용하였으며, 고순도의 Affinity Chromatography 정제 제품입니다. PBS buffer에 0.09% sodium azide를 포함하고 -20°C에서 보관합니다.
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Applications
- Western Blot (WB): 0.2–1 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide directed towards the N-terminal of human MRPS12 (aa 20–69) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS with 2% sucrose |
| Contains | 0.09% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2610370 |
Product Specific Information
- Peptide sequence: LVPRLWATCS MATLNQMHRL GPPKRPPRKL GPTEGRPQLK GVVLCTFTRK
- Sequence homology:
- Cow: 86%
- Dog: 91%
- Guinea Pig: 86%
- Horse: 79%
- Human: 100%
- Rat: 86%
Target Information
Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and are essential for mitochondrial protein synthesis. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit, with approximately 75% protein and 25% rRNA composition, contrasting with prokaryotic ribosomes. Unlike prokaryotic ribosomes, mammalian mitoribosomes lack a 5S rRNA component. The MRPS12 gene encodes a 28S subunit protein belonging to the ribosomal protein S12P family, which is crucial for decoding fidelity and aminoglycoside antibiotic susceptibility. This gene is located adjacent to the mitochondrial seryl-tRNA synthetase gene and may be associated with autosomal dominant deafness (DFNA4). Multiple splice variants exist but encode the same protein.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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